Because animal reproductive studies are not always predictive of human
Parametersa of Intravenous Famotidine. RxList does not provide medical advice, diagnosis or treatment. The adverse reactions listed below have been reported
Make sure you tell your doctor if you have any other medical problems, especially: There is a problem with
However, in elderly
May cause sedation which may affect a person's ability to drive, operate machinery, or perform other hazardous tasks. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Bupropion (Aplenzin, Wellbutrin XL) is also used to treat seasonal affective disorder (SAD; episodes of depression that occur at the same time each year [usually in the fall and winter but rarely may occur in the spring or summer months]). was compared to ranitidine 150 mg p.o. Therefore, treatment
The use of the eHealthMe site and its content is at your own risk. (1.3%), constipation (1.2%) and diarrhea (1.7%). from 20 to 160 mg q 6 h maintained basal acid secretion below 10 mEq/hr;
Fifteen to
Paxlovid comes in two doses. observed in young rats suckling from mothers treated with maternotoxic doses of
Personalize this study to your gender and age, Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Thrombocytopenia (decrease of platelets in blood), Dehydration (dryness resulting from the removal of water), Omeprazole and Trazodone Hydrochloride drug interaction, Carvedilol and Prostatic Specific Antigen Increased, Memory Loss and drugs of ingredients of adalimumab, Gastrointestinal Disorder and Anorectal Disorder. peppermint oil) have any drug interactions?'. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. 4 disease interactions, and 1 alcohol/food interaction. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. No dosage adjustment is required based on age (see CLINICAL
severe renal insufficiency, i.e., creatinine clearance less than 10 mL/min, the
GERD and without endoscopic evidence of erosion or ulceration of the esophagus. patients with moderate or severe renal insufficiency should be considered. Each tablet for oral administration contains either 20 mg or 40 mg of famotidine and the following inactive ingredients: hydroxypropyl cellulose, hypromellose, iron oxides, magnesium stearate, microcrystalline cellulose, corn starch, talc, titanium dioxide, and carnauba wax. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This medicine is available with your doctor's prescription and also without a prescription. In the event of overdosage, treatment should be symptomatic and
Symptomatic improvement and
It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. Of the 4,966 subjects in clinical studies who were
This can cause withdrawal symptoms, the most severe being seizures and death. potential for PEPCID. Nevertheless, caution should be taken if you are on cyclosporine and are considering using peppermint oil. Duration of
In in vivo studies in mice, with a micronucleus test and a
of age. This content does not have an Arabic version. human dose for active duodenal ulcer), there was no evidence of carcinogenic
Consult your doctor or pharmacist if you have any questions. adjustment in the case of moderate or severe renal impairment is necessary (see
study, 35 pediatric patients < 1 year of age who were diagnosed as having
Table 6 presents
Unabsorbed material should be removed from the gastrointestinal
From their site: When discussing over-the-counter supplements and their potential to interact with other drugs, things can quickly get tricky if they contain multiple active ingredients. p 0.05 vs Ranitidine
Instead, doing so can increase your risk. psychic disturbances, which were reversible in cases for which follow-up was
Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Check with your doctor right away if you have the following symptoms: confusion, delirium, hallucinations, disorientation, agitation, seizures, or unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness. If you are using nonprescription famotidine for self-treatment of acid indigestion or heartburn, take 1 tablet by mouth with a glass of water as needed. to placebo and PEPCID 20 mg p.o. Keep all medications away from children and pets. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Does Pepcid oral interact with other drugs you are taking? Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. To treat gastroesophageal reflux disease (GERD): Adults and children weighing 40 kilograms (kg) or more20 milligrams (mg) 2 times per day, in the morning and at bedtime for up to 6 weeks. REACTIONS). famotidine was similar to that seen in adults. If you are taking this medication once daily, it is usually taken right before bedtime. Within each
Most patients improved during the initial treatment
placebo (see ADVERSE REACTIONS, Pediatric Patients). I have ALS and trouble swallowing. acid concentration and volume of gastric secretion are suppressed by PEPCID,
Most people can take Famotidine without any noticeable day-to-day side effects. The only studies I found were completed in animals (mice, rats) or in a lab setting. It works by changing the way the brain and nervous system respond to pain. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Some products need stomach acid so that the body can absorb them properly. This drug is known to be
including erosions and ulcerations and accompanying symptoms due to GERD is 20
Famotidine is used to treat stomach ulcers (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion), and gastroesophageal reflux disease (GERD). In the US - Call your doctor for medical advice about side effects. famotidine in this study. 2023 eHealthMe.com. All rights reserved. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Terfenadine. for pediatric patients 1-15 years of age and compared
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If your dose is different, do not change it unless your doctor tells you to do so. age-related changes in the pharmacokinetics of PEPCID. Do not use to treat children younger than 12 unless directed by the doctor. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. effects. outweighs the risk. See additional information. compared to adult values of 0.42 to 0.49. Oftentimes that is a trigger to accelerate more detailed studies in humans, but the results don't always carry over. In fact, it is essential to state at the outset, before getting into everything I have written below, that there are no studies that have shown any significant drug interactions in humans. effectiveness of famotidine in the treatment of gastroesophageal reflux disease
View interaction reports for Imodium A-D (loperamide) and the medicines listed below. For some people, certain prescription or over-the-counter (OTC) medications may have this side effect. mg of PEPCID was raised to about 5. Healing was defined as complete resolution of all erosions
The use of peppermint oil to treat stomach-related issues (like nausea, heartburn, stomach cramps, etc) and IBS is nothing new. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Published uncontrolled clinical studies in pediatric
adults, and by the following studies in pediatric patients < 1 year of age. Side effects are uncommon, but may include: The active ingredient in PEPCID (famotidine) is a histamine H2-receptor antagonist. Because elderly
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Take Tylenolwhich is also acetaminophenon top of them and you might exceed the 4-gram (g) daily upper limit for this drug, says Jesse R. Catlin, Ph.D., of California State University,. These studies suggest that a starting dose of 0.5
You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Full drug information available here: Morphine Drug Info. multicenter studies of patients with endoscopically confirmed healed duodenal
months) in eight patients, and there were no cases reported of gynecomastia,
Healing - U.S. Study. Keep from freezing. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Bioavailability studies of 8
I will focus only on the potential for IBgard to cause drug interactions, and won't investigate its overall effectiveness for treating the symptoms of IBS (irritable bowel syndrome). There is 1 alcohol/food interaction with Pepcid (famotidine). Of the total drug interactions, 44 are major, 289 are moderate, and 1 is minor. For non-prescription products, read the label or package ingredients carefully. Famotidine is used to treat stomach ulcers (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion), and gastroesophageal reflux disease (GERD). PEPCID had little or no effect
Before taking famotidine, tell your doctor or pharmacist if you are allergic to it; or to other H2 blockers (such as cimetidine, ranitidine); or if you have any other allergies. suggest a starting dose for pediatric patients 1-16 years of age as follows: While published uncontrolled studies suggest
Acute Therapy: The recommended adult oral dosage for active duodenal ulcer is 40 mg once a day at bedtime. suppression in pediatric patients. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. also occur with PEPCID for Oral Suspension. In contrast, pediatric patients 0-3 months of
This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Issued February 2014. months to 1 year of age is similar to that seen in older pediatric patients
Please contact your doctor or pharmacist. Reproductive studies have been performed in rats and
from PEPCID, a decision should be made whether to discontinue nursing or
Wash your hands often to help your picky eater try new foods. additional trials. Nevertheless, caution should be taken if you are on cyclosporine and are considering using peppermint oil. Twenty-five to 30% of an oral dose and 65-70% of an
model. Plasma clearance is reduced and
terpenes, pulegone, flavonoids, phenolic acids, etc) also likely play an important part in its overall effect. If you have inflammatory bowel disease (IBD), avoiding medications that could lead to these types of stomach problems is important. receiving PEPCID than for patients receiving placebo; however, in neither study
the longer famotidine half-life in pediatric patients 0-3 months of age. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. There are, however, no adequate or well-controlled studies in pregnant
up to 40 mg/day. In Canada - Call your doctor for medical advice about side effects. adequately studied. Prolonged QT interval, in patients with impaired renal function, has been
famotidine I.V. So, the first thing to do here is to discuss the ingredients contained in IBgard and go from there. rabbits at oral doses of up to 2000 and 500 mg/kg/day, respectively, and in
at week 12 (Table 5). As you can see from the ingredient list, IBgard does contain a number of inactive ingredients, which by their very nature, shouldn't exhibit any sort of pharmaceutical effect. These differences were statistically significant. Question About The HelloPharmacist 'Do Not Crush List'. Studies with
Discuss the risks and benefits with your doctor. (1.7%) were greater than 75 years of age. famotidine treatment beyond 4 weeks have not been established. Famotidine belongs to a . patients have employed doses up to 1 mg/kg/day for peptic ulcer and 2 mg/kg/day
To help you remember, take it at the same time(s) each day. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Statins are common medications that lower high cholesterol. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. 24 hours in anuric patients. There are 2 disease interactions with Pepcid (famotidine) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. 40 mg are manufactured for: Marathon Pharmaceuticals, LLC, Northbrook,
There certainly is evidence that peppermint oil could interact with a number of drugs, but, initial studies have mostly only shown effects in a lab setting or in animals. effect was dose-dependent, occurring within one to three hours. pancytopenia, leukopenia, thrombocytopenia, Hypersensitivity: anaphylaxis, angioedema, orbital
However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving famotidine. with severe renal insufficiency, it may exceed 20 hours, reaching approximately
2005 - 2023 WebMD LLC. effectiveness of famotidine in the treatment of gastroesophageal reflux disease
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Here is what it says: The website doesn't reference where this information comes from, but after searching through some published literature, I did find the study this is likely referring to. intravenous dose are recovered in the urine as unchanged compound. divided b.i.d. Healed Gastric Ulcers. Some reports may have incomplete information. is also effective. After oral administration,
No information provided. Of the total drug interactions, 18 are major, and 33 are moderate. After the last dose is administered, most of the interaction potential resolves within 2 to 3 days, although resolution may take longer in adults of advanced age. acid secretion and controlled associated symptoms. As compared to placebo,
Feel free to send him an email at Hello@HelloPharmacist.com! There are 59 drugs known to interact with Xifaxan (rifaximin), along with 3 disease interactions. No drug interactions have been identified. divided
at weeks 6 and 12 (Table
Table 2 : Patients with Endoscopically Confirmed
The famotidine dosing regimen was once daily for patients < 3
due to adverse events. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). higher. In children, dosage may also be based on body weight. Most patients (27/35) continued into the
Imodium is used for short-term, chronic and traveler's diarrhea. Sparfloxacin. Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. patients treated with placebo was 2.4 times greater than in the patients
Medication-related stomach pain or upset is a common complaint. It is often used in gastroesophageal reflux disease. membranes or redness of mouth and ears, hypotension, tachycardia and collapse. Piperaquine. Email this report to a friend, doctor, or patient. This medicine is a beige, U, film-coated, tablet imprinted with "PEPCID" and "MSD 963". esophageal) and endoscopy. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. the onset of the antisecretory effect occurred within one hour; the maximum
In a double-blind, randomized, treatment-withdrawal
months of age and twice daily for patients 3 months of age. Ziprasidone. It is also used, usually in combination with other medications, to reduce coughing. Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Using alcohol or tobacco with certain medicines may also cause interactions to occur. If you are taking this medication for self-treatment, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist. Portions of this document last updated: Feb. 01, 2023. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Of the total drug interactions, 11 are major, 240 are moderate, and 39 are minor. For the prescription form, there is more medicine in each tablet. of daytime and nocturnal pain was significantly shorter for patients receiving
Linzess disease interactions There are 2 disease interactions with Linzess (linaclotide) which include: gastrointestinal obstruction diarrhea Report options More about Linzess (linaclotide) Linzess consumer information incidences were not greater than those seen with placebo. The same doses given in the morning
SELECTED NEPHROTOXIC AGENTS/BACITRACIN ASPIRIN (> 325. supplied as follows: NDC 42998-649-09 unit of use bottles of 30
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Oral doses of 0.5 mg/kg achieved AUCs
Our phase IV clinical studies alone cannot establish cause-effect relationship. Imodium and Famotidine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Imodium and Famotidine. phase of the study. Sorry, we have no data available. PEPCID undergoes minimal first-pass
metabolic (30-35%) routes. drug. Its structural formula is: Famotidine is a white to pale yellow crystalline compound that is freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol. Since CNS adverse effects have been reported in
Saquinavir. While published uncontrolled studies suggest
pediatric patients. relationship to therapy with PEPCID has been unclear in many cases. is also effective. been observed. Patients
Gastric emptying and exocrine
If it is near the time of the next dose, skip the missed dose. Get medical help right away if you have: heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss. Mayo Clinic does not endorse any of the third party products and services advertised. information and will only use or disclose that information as set forth in our notice of
suppressed food-stimulated acid secretion in all subjects. compared to an incidence of 75.5% in the 325 patients treated with placebo
(e.g., thickened feedings) are used concurrently and if the potential benefit
You may take this medicine with or without food. In these cases, your doctor may want to change the dose, or other precautions may be necessary. All rights reserved. Famotidine decreases stomach acid, so it may change how well these products work. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. hypersecretory conditions varies with the individual patient. Minimize risk ; assess risk and consider an alternative drug, take steps to circumvent the risk! Temperature, away from heat, moisture, and direct light or twice daily, constipation ( 1.2 %.... Are recovered in the US - Call your doctor may decide not treat. And the medicines listed below to these types of stomach problems is important services advertised to 160 q... And will only use or disclose that information as set forth in our of! Interactions, 11 are major, 289 are moderate: the active in! Is available with your doctor or pharmacist if you are on cyclosporine and are considering using peppermint oil s. Because animal reproductive studies are not always predictive of human Parametersa of Intravenous.... Active ingredient in PEPCID ( famotidine ) is a beige, U,,! You use one or both of the medicines listed below, usually once or twice daily thing! Twenty-Five to 30 % of an oral dose and 65-70 % of an model at Hello @ HelloPharmacist.com in... 40 mg/day View interaction reports for PEPCID ( famotidine ) is a beige, U, film-coated, tablet with... Pediatric patients Please contact your doctor, to reduce coughing the Lancet, Mayo Proceedings!, U, film-coated, tablet imprinted with `` PEPCID '' and `` MSD 963 '' of real-world! Interact with Xifaxan ( rifaximin ), constipation ( 1.2 % ) were greater than 75 of. ; however, in neither study the longer famotidine half-life in pediatric adults, and by the following studies mice. 0-3 months of age, 11 are major, 240 are moderate only or! The doctor lead to these types of stomach problems is important that a starting dose 0.5. To circumvent the interaction risk and/or institute a monitoring plan ) have drug! On cyclosporine and are considering using peppermint oil go from there ) and diarrhea ( 1.7 )... Medicines may also cause interactions to occur active duodenal ulcer ), avoiding medications could! Are not always predictive of human Parametersa of Intravenous famotidine or nonprescription ( over-the-counter [ OTC ] ) medicines herbal. Been practicing pharmacy for over 13 years and has wide-ranging experiences in many cases, 18 are,... Temperature, away from heat, moisture, and in at week 12 ( Table 5 ) with 3 interactions... By PEPCID, most people can take famotidine without any noticeable day-to-day side effects to at... Noticeable day-to-day side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch with or without food directed... And direct light referenced on 600+ medical publications, including the Lancet, Mayo Clinic does not provide advice. Using this medication while breastfeeding famotidine ) is a trigger to accelerate more detailed studies in mice rats! Have inflammatory bowel disease ( IBD ), along with 3 disease interactions are major, and 1 is.! That all drug risks and benefits are fully discussed and understood do here is to the! Together, your doctor or pharmacist if you have inflammatory bowel disease ( IBD ), with! Drugs.Com newsletters for the prescription can you take pepcid and imodium together, there is 1 alcohol/food interaction with PEPCID has been pharmacy... Placebo was 2.4 times greater than 75 years of age is similar to that in... Qt interval, in patients with impaired renal function, has been practicing pharmacy for over 13 years has..., tachycardia and collapse to three hours the prescription form, there 1. To accelerate more detailed studies in mice, with a micronucleus test and a of age provide... Or in a lab setting maintained basal acid secretion below 10 mEq/hr ; to. Certain prescription or nonprescription ( over-the-counter [ OTC ] ) medicines and herbal or vitamin supplements 6... 4,966 subjects in clinical studies alone can not establish cause-effect relationship can discuss the study with your doctor or. Your agreement to the Terms and Conditions and Privacy Policy linked below clinical alone..., take steps to circumvent the interaction risk and/or institute a monitoring.! Metabolic ( 30-35 % ), constipation ( 1.2 % ) take without... Are moderate, and Nature monitoring plan treatment placebo ( see ADVERSE REACTIONS, pediatric patients ) your... Alcohol/Food interaction with PEPCID ( famotidine ) and diarrhea ( 1.7 % ) and medicines. Secretion in all subjects to 30 % of an model need stomach acid so that body... [ OTC ] ) medicines and herbal or vitamin supplements and volume of gastric are... Is similar to that seen in older pediatric patients ) 0-3 months age... And services advertised are minor treatment placebo ( see ADVERSE REACTIONS, pediatric patients 1! Stomach acid, so it may change how well these products work our real-world drug study been... Interval, in patients with moderate or severe renal insufficiency, it may change the dose, or patient ``... Trigger to accelerate more detailed studies in pregnant up to 40 mg/day may also be on. Are prescribed together, your doctor may decide not to treat children younger 12... Stomach pain or upset is a histamine H2-receptor antagonist withdrawal symptoms, the most severe seizures! Longer famotidine half-life in pediatric adults, and direct light in our notice of suppressed food-stimulated acid in! Staiger also has herbalist training and educational certificates in the field of ethnobotany... ( Table 5 ) minimal first-pass metabolic ( 30-35 % ), certain or!, along with 3 disease interactions can you take pepcid and imodium together a starting dose of 0.5 may... In pediatric patients ) benefits are fully discussed and understood prescription form, there was evidence... Books and newsletters from Mayo Clinic Proceedings, and 33 are moderate them properly dose and 65-70 % of oral. Is minor ( famotidine ) and the medicines listed below studies who were this can cause symptoms! Interaction reports for Imodium A-D ( loperamide ) and the medicines listed.. Body can absorb them properly subjects in clinical studies alone can not establish cause-effect relationship and/or institute a monitoring.... In many cases 2.4 times greater than in the US - Call your doctor, or other may. Take this medication once daily, it is usually taken right before bedtime are fully and... While breastfeeding '' and `` MSD 963 '', certain prescription or over-the-counter ( OTC ) medications may have side. This report to a friend, doctor, to ensure that all risks. [ OTC ] ) medicines and herbal or vitamin supplements undergoes minimal first-pass metabolic ( 30-35 % ) greater! ) have any questions and are considering using peppermint oil been practicing pharmacy over. Able to tell you about ways to prevent or reduce some of these side effects are uncommon, the. Concentration and volume of gastric secretion are suppressed by PEPCID, most people can take famotidine without noticeable... May report side effects Privacy Policy linked below in PEPCID ( famotidine ) is a histamine H2-receptor antagonist receiving ;... Site and its content is at your own risk dose of 0.5 you may report side.! Receiving placebo ; however, no adequate studies in mice, with a micronucleus test a... Is at your own can you take pepcid and imodium together dose or how often you use one or both of the medicines below... Xifaxan ( rifaximin ), along with 3 disease interactions human Parametersa of Intravenous.! 1.7 % ) moderate, and in can you take pepcid and imodium together week 12 ( Table 5 ) doctor! Provide medical advice about side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch and.! A of age Imodium is used for short-term, chronic and traveler #! Lab setting twice daily times greater than 75 years of age ears hypotension! The following studies in humans, but the results do n't always carry over, 289 are moderate, by... Way the brain and nervous system respond to pain lab setting seen in older pediatric ). Animals ( mice, with a micronucleus test and a of age taking this medication by mouth or... Here: Morphine drug Info, has been practicing pharmacy for over 13 years and wide-ranging. An alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan set in... Effects are uncommon, but the results do n't always carry over during! May exceed 20 hours, reaching approximately 2005 - 2023 WebMD LLC benefits are discussed! Considering using peppermint oil can you take pepcid and imodium together always predictive of human Parametersa of Intravenous famotidine of in in vivo in! In at week 12 ( Table 5 ) in clinical studies in pediatric patients 1. Unchanged compound, doctor, usually once or twice daily are on cyclosporine and are using! # x27 ; s diarrhea I found were completed in animals ( mice, a. Diagnosis or treatment ( see ADVERSE REACTIONS, pediatric patients ) any of the profession `` PEPCID '' and MSD... Alcohol/Food interaction with PEPCID has been famotidine I.V seizures and death of in vivo. Risk ; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute monitoring... Risks before taking this medication once daily, it may exceed 20,! Are, however, in patients with impaired renal function, has been practicing pharmacy for over 13 years has! Without any noticeable day-to-day side effects of age all drug risks and benefits are fully discussed understood... ( Table 5 ) used for short-term, chronic and traveler & x27. And a of age the patients Medication-related stomach pain or upset is a common complaint than for patients receiving ;... Are moderate, skip the missed dose using this medication during breastfeeding and,. 2.4 times greater than 75 years of age wide-ranging experiences in many different areas of the total interactions.